Cancer Chemopreventive Properties of Citrus Limonoids
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Limonoids constitute one of the major phytochemicals along with flavonoids, coumarins, and carotenoids in citrus. Limonoids were shown to possess cancer preventive properties. In the past quarter century, a number of studies have accumulated considerable evidence, which advanced our understanding about the disease prevention mechanism of limonoids. It is speculated that limonoids suppress cell proliferation and induce apoptosis by inhibiting enzyme activities and signal transduction pathways. In addition, limonoids were also shown to inhibit cell metastasis in cell culture and animal studies. However, further research is required to identify the cellular targets of active limonoids. Identification of the target mechanism at cellular level may result in the development of limonoids as anticancer agents. In the present chapter, the diverse role and the biological activities of limonoids relating to their potential in cancer prevention are discussed. © 2012 American Chemical Society.
EMERGING TRENDS IN DIETARY COMPONENTS FOR PREVENTING AND COMBATING DISEASE
author list (cited authors)
Kim, J., Jayaprakasha, G. K., Vikram, A., & Patil, B. S.
complete list of authors
Kim, Jinhee||Jayaprakasha, GK||Vikram, Amit||Patil, Bhimanagouda S
Digital Object Identifier (DOI)
International Standard Book Number (ISBN) 13
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