Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity? Academic Article uri icon


  • Pb2+ is a xenobiotic metal ion that competes for Ca2+-binding sites in proteins. Using the peripheral Ca2+-sensing domains of Syt1, we show that the chelating pH buffer Bis-Tris enables identification and functional characterization of high-affinity Pb2+ sites that are likely to be targeted by bioavailable Pb2+.

published proceedings

  • Metallomics

altmetric score

  • 0.25

author list (cited authors)

  • Katti, S., & Igumenova, T. I.

citation count

  • 1

complete list of authors

  • Katti, Sachin||Igumenova, Tatyana I

publication date

  • February 2020