Extracellular Vesicles as Therapeutics for Brain Injury and Disease. Academic Article

abstract

• Extracellular vesicles (EVs) are gaining tremendous importance in comprehending central nervous system (CNS) function and treating neurological disorders because of their role in intercellular communication and reparative processes, and suitability as drug delivery vehicles. Since EVs have lipid membranes, they cross the blood-brain barrier easily and communicate with target neurons and glia even deep inside the brain. EVs from various sources have been isolated, characterized, and tailored for promoting beneficial effects in conditions, such as brain injury and disease. Particularly, EVs isolated from mesenchymal stem cells and neural stem cells have shown promise for alleviating brain dysfunction after injury or disease. Such properties of stem cell-derived EVs have great importance for clinical applications, as EV therapy can avoid several concerns typically associated with cell therapy. This minireview confers the competence of EVs for improving brain function by modulating CNS injury and disease.

authors

• Shetty, Ashok

published proceedings

• Curr Pharm Des

author list (cited authors)

• Upadhya, D., & Shetty, A. K.

citation count

• 20

complete list of authors

• Upadhya, Dinesh||Shetty, Ashok K

publication date

• November 2019

publisher

• BENTHAM SCIENCE PUBLISHERS  Publisher

published in

• Current Pharmaceutical Design  Journal

keywords

• Blood-Brain Barrier
• Brain Diseases
• Brain Injuries
• Brain Injury
• Drug Delivery Systems
• Exosomes
• Extracellular Vesicles
• Humans
• Mesenchymal Stem Cells
• Neural Stem Cells
• Neurodegenerative Diseases.

PubMed Central ID

• 31612823

Digital Object Identifier (DOI)

• 10.2174/1381612825666191014164950

start page

• 3500

end page

• 3505

volume

• 25

issue

• 33

URL

• http://dx.doi.org/10.2174/1381612825666191014164950