Neurobiology of Procedural Learning in Animals
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2017 Elsevier Ltd. All rights reserved. Procedural learning and memory involves the acquisition, consolidation, and retrieval of individual representations that are behaviorally expressed in an inflexible manner. Stimulus-response habit learning represents a prominent form of procedural learning in the mammalian brain. Extensive evidence supports the hypothesis that this form of procedural learning is mediated by a neural system that contains the dorsal striatum as a primary component. Studies employing brain lesion techniques have dissociated the roles of the dorsal striatum and hippocampus in procedural and declarative memory, respectively. Pharmacological studies indicate a selective role for dorsal striatal dopamine, acetylcholine, glutamate, and cannabinoids in stimulus-response procedural learning.