Neurofibromatosis 1 mRNA expression in blood vessels. Academic Article uri icon


  • Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.

published proceedings

  • Biochem Biophys Res Commun

author list (cited authors)

  • Ahlgren-Beckendorf, J. A., Maggio, W. W., Chen, F., & Kent, T. A.

citation count

  • 21

complete list of authors

  • Ahlgren-Beckendorf, JA||Maggio, WW||Chen, F||Kent, TA

publication date

  • December 1993