Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent. Academic Article

abstract

• We have applied a superparamagnetic iron oxide formulation (AMI-25, Advanced Magnetics, Inc., Cambridge, MA) to image the cerebral vasculature. Contrast-enhanced images of normal anesthetized rats demonstrated excellent gray/white matter differentiation, consistent with known differences in blood perfusion, and cerebrospinal fluid spaces were clearly seen. Alterations in normal perfusion patterns due to barbiturate anesthesia and ischemia were clearly visible. We propose the use of this agent as an adjunct to MRI for the imaging of conditions with perfusion abnormalities.

authors

• Kent, Thomas

published proceedings

• Magn Reson Med

author list (cited authors)

• Kent, T. A., Quast, M. J., Kaplan, B. J., Lifsey, R. S., & Eisenberg, H. M.

citation count

• 53

complete list of authors

• Kent, TA||Quast, MJ||Kaplan, BJ||Lifsey, RS||Eisenberg, HM

publication date

• March 1990

publisher

• Wiley  Publisher

published in

• Magnetic Resonance in Medicine  Journal

keywords

• Animals
• Brain
• Cerebrovascular Circulation
• Contrast Media
• Evaluation Studies As Topic
• Ferric Compounds
• Magnetic Resonance Imaging
• Male
• Rats
• Rats, Inbred Strains

PubMed Central ID

• 2325543

Digital Object Identifier (DOI)

• 10.1002/mrm.1910130310

start page

• 434

end page

• 443

volume

• 13

issue

• 3

URL

• http://dx.doi.org/10.1002/mrm.1910130310