Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation. Academic Article

abstract

• Increases in inspired CO2 consistently altered the local concentration of the brain extracellular space marker alpha-naphthalene sulfonate (alpha-NS) as measured with ion-selective micropipettes in the rat thalamus. Stereotaxic injection of lidocaine in the region of the locus coeruleus attenuated this effect of CO2, and amitriptyline, a tricyclic anti-depressant and amine reuptake inhibitor, potentiated the effect. These results suggest that metabolic demand, as mimicked here by the addition of CO2, alters the fluid environment of the brain and central noradrenergic mechanisms may modulate this response.

authors

• Kent, Thomas

published proceedings

• Brain Res

author list (cited authors)

• Kent, T. A., Nagy, G., Oke, A. F., Preskorn, S. H., & Adams, R. N.

citation count

• 8

complete list of authors

• Kent, TA||Nagy, G||Oke, AF||Preskorn, SH||Adams, RN

publication date

• September 1985

publisher

• Elsevier  Publisher

published in

• BRAIN RESEARCH  Journal

keywords

• Amitriptyline
• Animals
• Brain
• Carbon Dioxide
• Extracellular Space
• Lidocaine
• Locus Coeruleus
• Male
• Naphthalenesulfonates
• Norepinephrine
• Rats
• Rats, Inbred Strains

PubMed Central ID

• 3929997

Digital Object Identifier (DOI)

• 10.1016/0006-8993(85)91362-9

start page

• 141

end page

• 144

volume

• 342

issue

• 1

URL

• http://dx.doi.org/10.1016/0006-8993(85)91362-9