Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation. Academic Article

abstract

• The cerebromicrocirculation in the tetrabenzaine (TBZ) model of depression has been found to be abnormal with respect to (1) responsiveness of cerebral blood flow to increases in arterial CO2 content and (2) the effective permeability of the blood-brain barrier to water. Development of these abnormalities temporally paralleled the behavioral disturbances and catecholamine depletion induced by TBZ. These TBZ-induced changes occurred globally throughout the brain, being apparent in the forebrain, cerebellum, and medulla-pons. Pretreatment with the antidepressant amitriptyline prevented both behavioral and physiological effects of TBZ, whereas amitriptyline administered after TBZ was less effective. The results suggest that an important action of tricyclic antidepressants may be cerebromicrocirculatory effects.

authors

• Kent, Thomas

published proceedings

• Biol Psychiatry

author list (cited authors)

• Kent, T. A., Preskorn, S. H., Glotzbach, R. K., & Irwin, G. H.

citation count

• 10

complete list of authors

• Kent, TA||Preskorn, SH||Glotzbach, RK||Irwin, GH

publication date

• May 1986

publisher

• Elsevier  Publisher

published in

• Biological Psychiatry  Journal

keywords

• Amitriptyline
• Animals
• Behavior, Animal
• Blood-Brain Barrier
• Cerebrovascular Circulation
• Dopamine
• Male
• Microcirculation
• Norepinephrine
• Rats
• Rats, Inbred Strains
• Serotonin
• Tetrabenazine

PubMed Central ID

• 3697438

Digital Object Identifier (DOI)

• 10.1016/0006-3223(86)90190-3

start page

• 483

end page

• 491

volume

• 21

issue

• 5-6

URL

• http://dx.doi.org/10.1016/0006-3223(86)90190-3