Cerebromicrocirculatory defects in animal model of depression. Academic Article

abstract

• In the tetrabenazine (TBZ) model of depression, the cerebromicrocirculation was discovered to respond abnormally to metabolic demand as mimicked by the administration of CO2. Altered responsivity of cerebral blood flow and effective permeability of the blood--brain barrier to changes in PaCO2 were found. These physiologic defects coincided temporally with TBZ-induced depletion of central norepinephrine and dopamine and with the development of the behavioral effects of TBZ (the end points used to test the antidepressant potential of experimental drugs). Pretreatment with amitriptyline (a standard antidepressant and amine reuptake inhibitor) prevented the development of these TBZ-induced abnormalities in the cerebromicrocirculation, just as it prevented the behavioral effects.

authors

• Kent, Thomas

published proceedings

• Psychopharmacology (Berl)

author list (cited authors)

• Preskorn, S. H., Kent, T. A., Glotzbach, R. K., Irwin, G. H., & Solnick, J. V.

citation count

• 14

complete list of authors

• Preskorn, SH||Kent, TA||Glotzbach, RK||Irwin, GH||Solnick, JV

publication date

• October 1984

publisher

• Springer Nature  Publisher

published in

• Psychopharmacology  Journal

keywords

• Amitriptyline
• Animals
• Brain
• Carbon Dioxide
• Cerebrovascular Circulation
• Depression
• Disease Models, Animal
• Dopamine
• Humans
• Male
• Microcirculation
• Norepinephrine
• Rats
• Rats, Inbred Strains
• Tetrabenazine

Digital Object Identifier (DOI)

• 10.1007/BF00427445

start page

• 196

end page

• 199

volume

• 84

issue

• 2

URL

• http://dx.doi.org/10.1007/bf00427445