The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain.

abstract

• We examined the effects of the 21-aminosteroid antioxidant U-74389G (16-desmethyl-tirilazad) on the concentration of extracellular superoxide anion following fluid percussion traumatic brain injury (TBI) measured by a cytochrome c-coated electrode and on local cerebral perfusion (CBFld) measured by laser Doppler flowmetry (LDF). U-74389G in a dose of 3 mg/kg reduced superoxide anion concentrations 60 min after TBI significantly but had no significant effect on CBFld. These results indicate that reduction of CBF after TBI can be dissociated from superoxide anion production. Persistent ischemia may limit neuroprotection efficacy and may contribute to divergent outcome results in clinical and animal trials using agents to modify reactive oxygen species.

authors

• Kent, Thomas

published proceedings

• J Neurotrauma

author list (cited authors)

• Fabian, R. H., Dewitt, D. S., & Kent, T. A.

citation count

• 30

complete list of authors

• Fabian, RH||Dewitt, DS||Kent, TA

publication date

• June 1998

publisher

• Mary Ann Liebert  Publisher

published in

• JOURNAL OF NEUROTRAUMA  Journal

keywords

• Animals
• Antioxidants
• Brain
• Brain Injuries
• Cerebrovascular Circulation
• Electrochemistry
• Female
• Laser-Doppler Flowmetry
• Male
• Osmolar Concentration
• Pregnatrienes
• Rats
• Rats, Sprague-Dawley
• Superoxides
• Wounds, Nonpenetrating

PubMed Central ID

• 9624628

Digital Object Identifier (DOI)

• 10.1089/neu.1998.15.433

start page

• 433

end page

• 440

volume

• 15

issue

• 6

URL

• http://dx.doi.org/10.1089/neu.1998.15.433