In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. Academic Article uri icon


  • A cytochrome c-coated platinized carbon electrode was utilized to detect superoxide generated by the brain during hypoxia/hypercarbia, focal ischemia, and reperfusion and following fluid percussion brain injury with and without hemorrhagic hypotension and reperfusion in the rat. All three of these forms of brain injury were associated with an increase in the superoxide signal. The cytochrome c electrode proved to be sensitive and responsive enough for minute-by-minute measurement of superoxide generation by brain tissue.

published proceedings

  • J Cereb Blood Flow Metab

author list (cited authors)

  • Fabian, R. H., DeWitt, D. S., & Kent, T. A.

citation count

  • 107

complete list of authors

  • Fabian, RH||DeWitt, DS||Kent, TA

publication date

  • March 1995