5-HT1B and 5-HT2 serotonin binding sites in cultured Wistar-Kyoto rat aortic smooth muscle cells. Academic Article uri icon


  • We studied [3H]serotonin [( 3H]5-HT) binding on cultured arterial smooth muscle cells from rat aorta. We found a high and low affinity binding site. Binding to the higher affinity site could be displaced by drugs in an order corresponding most closely with the 5-HT1B subtype, and high affinity [125I]iodo-cyanopindolol binding was also found. We found evidence for a 5-HT2 subtype using [3H]ketanserin binding, with similar results whether specific binding was determined using unlabelled ketanserin, methysergide or mianserin.

published proceedings

  • Eur J Pharmacol

author list (cited authors)

  • Jazayeri, A., Meyer, W. J., & Kent, T. A.

citation count

  • 11

complete list of authors

  • Jazayeri, A||Meyer, WJ||Kent, TA

publication date

  • October 1989