Effect of hyperbaric oxygen on the blood: cerebrospinal fluid transfer of tobramycin.

abstract

• The blood:cerebrospinal fluid (CSF) transfer of the aminoglycoside antibiotic, tobramycin (TOB) was assessed in rabbits. The CSF:blood ratio of TOB, 90 min after a subcutaneous injection, was approximately 1:100 as measured by an agar disc diffusion bioassay. Hyperbaric oxygen therapy at a pressure of 3 ATA caused a slight, non-significant, increase in this ratio, while high dose carbon dioxide, a treatment known to damage the blood:brain barrier, more than doubled this ratio. Thus, hyperbaric oxygen has no significant effect on CSF concentration of TOB in rabbits with intact meninges.

authors

• Kent, Thomas

published proceedings

• Aviat Space Environ Med

author list (cited authors)

• Kent, T. A., Sheftel, T. G., Sutton, T. E., Morrison, L. T., & Mader, J. T.

citation count

• 5

complete list of authors

• Kent, TA||Sheftel, TG||Sutton, TE||Morrison, LT||Mader, JT

publication date

• July 1986

published in

• Aviation, Space, and Environmental Medicine  Journal

keywords

• Animals
• Blood-Brain Barrier
• Carbon Monoxide
• Hyperbaric Oxygenation
• Rabbits
• Tobramycin

PubMed Central ID

• 3741289

start page

• 664

end page

• 666

volume

• 57

issue

• 7