Effect of hyperbaric oxygen on the blood: cerebrospinal fluid transfer of tobramycin. Academic Article uri icon


  • The blood:cerebrospinal fluid (CSF) transfer of the aminoglycoside antibiotic, tobramycin (TOB) was assessed in rabbits. The CSF:blood ratio of TOB, 90 min after a subcutaneous injection, was approximately 1:100 as measured by an agar disc diffusion bioassay. Hyperbaric oxygen therapy at a pressure of 3 ATA caused a slight, non-significant, increase in this ratio, while high dose carbon dioxide, a treatment known to damage the blood:brain barrier, more than doubled this ratio. Thus, hyperbaric oxygen has no significant effect on CSF concentration of TOB in rabbits with intact meninges.

published proceedings

  • Aviat Space Environ Med

author list (cited authors)

  • Kent, T. A., Sheftel, T. G., Sutton, T. E., Morrison, L. T., & Mader, J. T.

citation count

  • 5

complete list of authors

  • Kent, TA||Sheftel, TG||Sutton, TE||Morrison, LT||Mader, JT

publication date

  • July 1986