Blood platelet uptake of serotonin in men alcoholics. Academic Article uri icon


  • Blood platelet uptake of 3H-serotonin (5HT uptake) was determined in a group of inpatient alcoholics who had just undergone detoxication (N = 19) and an age-matched group of nonalcoholic controls (N = 19). Mean 5HT uptake was 18% lower in the alcoholics (p less than .01). A 3-min 5HT uptake of less than 6 pmoles/10(7) platelets identified 58% of the alcoholics, but only 15% of the controls had a 5HT uptake lower than this value. These results support the hypothesis that serotonergic dysfunction may exist in alcoholics.

published proceedings

  • J Stud Alcohol

author list (cited authors)

  • Kent, T. A., Campbell, J. L., Pazdernik, T. L., Hunter, R., Gunn, W. H., & Goodwin, D. W.

citation count

  • 32

complete list of authors

  • Kent, TA||Campbell, JL||Pazdernik, TL||Hunter, R||Gunn, WH||Goodwin, DW

publication date

  • July 1985