Blood platelet uptake of serotonin in men alcoholics. Academic Article

abstract

• Blood platelet uptake of 3H-serotonin (5HT uptake) was determined in a group of inpatient alcoholics who had just undergone detoxication (N = 19) and an age-matched group of nonalcoholic controls (N = 19). Mean 5HT uptake was 18% lower in the alcoholics (p less than .01). A 3-min 5HT uptake of less than 6 pmoles/10(7) platelets identified 58% of the alcoholics, but only 15% of the controls had a 5HT uptake lower than this value. These results support the hypothesis that serotonergic dysfunction may exist in alcoholics.

authors

• Kent, Thomas

published proceedings

• J Stud Alcohol

author list (cited authors)

• Kent, T. A., Campbell, J. L., Pazdernik, T. L., Hunter, R., Gunn, W. H., & Goodwin, D. W.

citation count

• 32

complete list of authors

• Kent, TA||Campbell, JL||Pazdernik, TL||Hunter, R||Gunn, WH||Goodwin, DW

publication date

• July 1985

publisher

• Alcohol Research Documentation  Publisher

published in

• Journal of Studies on Alcohol and Drugs  Journal

keywords

• Adult
• Alcohol Withdrawal Delirium
• Alcoholism
• Blood Platelets
• Depressive Disorder
• Humans
• Male
• Middle Aged
• Serotonin

PubMed Central ID

• 4033134

Digital Object Identifier (DOI)

• 10.15288/jsa.1985.46.357

start page

• 357

end page

• 359

volume

• 46

issue

• 4

URL

• http://dx.doi.org/10.15288/jsa.1985.46.357