Hyperglycemia in acute ischemic stroke: a vascular perspective. Academic Article

abstract

• Admission hyperglycemia complicates approximately one-third of acute ischemic strokes and is associated with a worse clinical outcome. Both human and animal studies have showed that hyperglycemia is particularly detrimental in ischemia/reperfusion. Decreased reperfusion blood flow has been observed after middle cerebral artery occlusion in acutely hyperglycemic animals, suggesting the vasculature as an important site of hyperglycemic reperfusion injury. This paper reviews biochemical and molecular pathways in the vasculature that are rapidly affected by hyperglycemia and concludes that these changes result in a pro-vasoconstrictive, pro-thrombotic and pro-inflammatory phenotype that renders the vasculature vulnerable to reperfusion injury. Understanding these pathways should lead to the development of rational therapies that reduce hyperglycemic reperfusion injury and thus improve outcome in this large subset of acute ischemic stroke patients.

authors

• Kent, Thomas

published proceedings

• J Cereb Blood Flow Metab

author list (cited authors)

• Martini, S. R., & Kent, T. A.

citation count

• 180

complete list of authors

• Martini, Sharyl R||Kent, Thomas A

publication date

• March 2007

publisher

• SAGE Publications  Publisher

published in

• Journal of Cerebral Blood Flow and Metabolism  Journal

keywords

• Animals
• Brain
• Humans
• Hyperglycemia
• Reperfusion Injury
• Signal Transduction
• Stroke

PubMed Central ID

• 16804552

Digital Object Identifier (DOI)

• 10.1038/sj.jcbfm.9600355

start page

• 435

end page

• 451

volume

• 27

issue

• 3

URL

• http://dx.doi.org/10.1038/sj.jcbfm.9600355