The Fate of Molecular Oxygen in Azinomycin Biosynthesis
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The azinomycins are a family of aziridine-containing antitumor antibiotics and represent a treasure trove of biosynthetic reactions. The formation of the azabicyclo[3.1.0]hexane ring and functionalization of this ring system remain the least understood aspects of the pathway. This study reports the incorporation of 18O-labeled molecular oxygen in azinomycin biosynthesis including both oxygens of the diol that ultimately adorn the aziridino[1,2- a]pyrrolidine moiety. Likewise, two other sites of heavy atom incorporation are observed.
author list (cited authors)
Kelly, G. T., Washburn, L. A., & Watanabe, C.
complete list of authors
Kelly, Gilbert T||Washburn, Lauren A||Watanabe, Coran MH