The Fate of Molecular Oxygen in Azinomycin Biosynthesis Academic Article uri icon


  • The azinomycins are a family of aziridine-containing antitumor antibiotics and represent a treasure trove of biosynthetic reactions. The formation of the azabicyclo[3.1.0]hexane ring and functionalization of this ring system remain the least understood aspects of the pathway. This study reports the incorporation of 18O-labeled molecular oxygen in azinomycin biosynthesis including both oxygens of the diol that ultimately adorn the aziridino[1,2- a]pyrrolidine moiety. Likewise, two other sites of heavy atom incorporation are observed.

altmetric score

  • 0.75

author list (cited authors)

  • Kelly, G. T., Washburn, L. A., & Watanabe, C.

citation count

  • 6

complete list of authors

  • Kelly, Gilbert T||Washburn, Lauren A||Watanabe, Coran MH

publication date

  • January 2019