Serum lipase activity and canine pancreatic lipase immunoreactivity (cPLI) concentration in dogs with experimentally induced chronic renal failure. ID - 20103332642
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Assays for the measurement of pancreatic lipase concentration in dog serum (cPLI) have been suggested to be useful for the diagnosis of canine pancreatitis. Clinical signs of pancreatitis and renal failure can overlap. Previously, serum lipase activity has been reported to be increased in dogs with renal failure but the influence of renal failure on serum cPLI concentration has not been evaluated. The goal of this project was to examine the influence of experimentally induced Chronic Renal Failure (CRF) on serum lipase activity and cPLI concentration. Serum samples were collected from 17 dogs with experimentally-induced CRF and were analyzed for creatinine concentration, lipase activity and cPLI concentration. One of the dogs showed extreme results for both serum lipase activity and cPLI concentration but was shown to have histological evidence of pancreatitis and was removed from further analysis. Serum lipase activities and cPLI concentrations of the 16 remaining dogs were compared to the reference intervals for these parameters. Serum lipase activity was within the reference interval in all 16 dogs with experimentally induced chronic renal failure. Serum cPLI concentration was outside the reference interval for serum cPLI (2.2-02.1 g L-1) concentration for two dogs but below the suggested diagnostic cut-off value for pancreatitis (200 g L-1) in all 16 dogs. Dogs with experimentally induced chronic renal failure studied here did not have clinically relevant increases in serum lipase activity or serum cPLI concentration. Further studies in dogs with spontaneous renal failure are necessary and ongoing.