Endogenous Fluorescence Lifetime Imaging (FLIM) Endoscopy For Early Detection Of Oral Cancer And Dysplasia.

abstract

• We have performed a pilot clinical study, in which multispectral endogenous fluorescence (or autofluorescence) lifetime imaging (FLIM) was performed on clinically suspicious oral lesions of 73 patients undergoing tissue biopsy for oral dysplasia and cancer diagnosis. The results from this pilot study indicated that mild-dysplasia and early stage oral cancer could be detected from benign lesions using a computed aided diagnosis system developed based on biochemical and metabolic biomarkers derived from the endogenous FLIM images. The diagnostic performance of this novel FLIM clinical tool was estimated using a leave-onepatient-out cross-validation approach, which reported levels of sensitivity >90%, specificity >85%, and Area Under the Receiving Operating Curve (ROC-AUC) >0.9.

authors

• Cheng, Yi-Shing
• Wright, John

published proceedings

• Annu Int Conf IEEE Eng Med Biol Soc

author list (cited authors)

• Jo, J. A., Cheng, S., Cuenca-Martinez, R., Duran-Sierra, E., Malik, B., Ahmed, B., ... Reese, T.

citation count

• 18

complete list of authors

• Jo, Javier A||Cheng, Shuna||Cuenca-Martinez, Rodrigo||Duran-Sierra, Elvis||Malik, Bilal||Ahmed, Beena||Maitland, Kristen||Cheng, Yi-Shing Lisa||Wright, John||Reese, Terry

publication date

• July 2018

publisher

• Institute of Electrical and Electronics Engineers (IEEE)  Publisher

published in

• Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference  Journal

keywords

• Early Detection Of Cancer
• Endoscopy
• FLUORESCENCE
• Humans
• Mouth Neoplasms
• Optical Imaging
• Pilot Projects

PubMed Central ID

• 30441030

Digital Object Identifier (DOI)

• 10.1109/EMBC.2018.8513027

start page

• 3009

end page

• 3012

volume

• 2018

URL

• http://dx.doi.org/10.1109/embc.2018.8513027