Template-Free Fabrication of Aligned Nanoarray for Quantifying the Nanosurface-Single Cells Interaction Conference Paper uri icon

abstract

  • In this paper, we for the first-time synthesized vertically aligned polyaniline (PANI) nanowire arrays on flat-end AFM tips via template-free solution methods. 4-Aminothiophenol was used for tailoring the nucleation size, chain propagation and orientation of the PANI nanowires. The microscopy characterization indicated that diameter was centered at a mean of 33.7 nm with a standard deviation of 6.5 nm, and length was centered at a mean of 50.3 nm with a standard deviation of 7.6 nm. PANI nanowire arrays are non-toxic, low-cost, and tunable, and thus PANI nanowire-grown tips could perfectly simulate different nanosurfaces. Via the force spectroscopy, we demonstrate the feasibility in quantifying the nanostructure-cell interactions at the single cell level in real time with high reliability and accuracy. This work will enable a new tool in precisely quantifying the interactions of single living cells and nanosurface, and thus opens a new door to understand how single living cells sense and respond to the specific nanostructures.

name of conference

  • Volume 1: Additive Manufacturing; Bio and Sustainable Manufacturing

published proceedings

  • Volume 1: Additive Manufacturing; Bio and Sustainable Manufacturing

author list (cited authors)

  • Wang, B., Wang, L., & Wang, S.

citation count

  • 0

complete list of authors

  • Wang, Biran||Wang, Liming||Wang, Shiren

publication date

  • January 2018