2016 by Taylor & Francis Group, LLC. The exposure of populations worldwide to citrus fruits, and its many uses, has led to studies aimed at elucidating some of its interaction with genome activities. Citrus limonin and related compounds inhibit free radical generation and act as free radical scavengers. This property is beneficial in preventing the free radical damage to the genome, especially the histones and DNA itself from mutations. In addition, they also influence the blood cells and immune cells to protect from the pathogenic organisms by altering the activities of genes.