Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD. Academic Article

abstract

• Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.

authors

• Liberzon, Israel

published proceedings

• Exp Brain Res

author list (cited authors)

• Vanderheyden, W. M., Poe, G. R., & Liberzon, I.

citation count

• 35

complete list of authors

• Vanderheyden, William M||Poe, Gina R||Liberzon, Israel

publication date

• May 2014

publisher

• Springer Nature  Publisher

published in

• Experimental Brain Research  Journal

keywords

• Animals
• Disease Models, Animal
• Humans
• Locus Coeruleus
• Rodentia
• Sleep Wake Disorders
• Stress Disorders, Post-Traumatic
• Wounds And Injuries

PubMed Central ID

• 24623353

Digital Object Identifier (DOI)

• 10.1007/s00221-014-3890-4

start page

• 1575

end page

• 1584

volume

• 232

issue

• 5

URL

• http://dx.doi.org/10.1007/s00221-014-3890-4