Polyphenolic derivatives from mango (Mangifera Indica L.) modulate fecal microbiome, short-chain fatty acids production and the HDAC1/AMPK/LC3 axis in rats with DSS-induced colitis
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2018 Elsevier Ltd This study elucidated how polyphenols from mango (Mangifera Indica L.) affect gut microbiota composition and SCFAs production in rats with DSS-induced colitis. Rats were administered either control or mango beverage for nine weeks, exposed to three cycles of 3% DSS with a 2-week recovery period. Mango intake caused a significant increase in tannase-producing bacteria Lactobacillus plantarum and Lactococcus lactis (p = 0.0494 and 0.0312, respectively), and butyrate-producing bacteria Clostridium butyrium (p = 0.0494). The concentrations of butyrate and valerate were increased by 150% and 119% in mango group. Mango beverage intake reduced HDAC1 activity, and induced the expressions of AMPK and the ratio of cleaved/total LC3A/B. The butyrate and pyrogallol production by mango intake may have contributed to the modulation of the HDAC1/AMPK/LC3 axis, confirmed in vitro. These results suggest mango intake mitigates inflammation in a DSS-induced colitis model partly by altering microbial composition and SCFAs production, and modulating the HDAC1/AMPK/LC3 axis.
