Substrate and stereochemical specificity of the organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 toward p-nitrophenyl phosphotriesters. Academic Article uri icon


  • The enzyme OPAA hydrolyzes p-nitrophenyl phosphotriesters bearing substituents at the phosphorus center ranging in size from methyl to phenyl. The enzyme exhibits stereoselectivity toward the hydrolysis of chiral substrates with a preference for the Sp enantiomer.

published proceedings

  • Bioorg Med Chem Lett

author list (cited authors)

  • Hill, C. M., Wu, F., Cheng, T. C., DeFrank, J. J., & Raushel, F. M.

citation count

  • 33

complete list of authors

  • Hill, CM||Wu, F||Cheng, TC||DeFrank, JJ||Raushel, FM

publication date

  • January 2000