Evaluation of multivalent dendrimers based on melamine: kinetics of thiol-disulfide exchange depends on the structure of the dendrimer. Academic Article

abstract

• The rate of thiol-disulfide exchange of dansyl groups mediated by dithiothreitol depends on the structure of the dendrimer. In general, the rate of exchange decreases as the size of the dendrimer increases. Dendrimers with disulfides attached near the core undergo exchange more slowly than dendrimers with disulfides near the periphery. Exchange is a bimolecular (noncooperative) process between dansyl-linked disulfides and dithiothreitol. No evidence for intramolecular macrocylization (cooperative) exchange is observed. Mass spectrometry is used to follow exchange in two dendrimers, providing qualitative and quantitative information about this process. Mathematical models suggest that the rates for exchange for all disulfides of a dendrimer are similar, but increase as the exchange reaction progresses.

authors

• Lindahl, Paul
• Perez, Lisa

published proceedings

• J Am Chem Soc

altmetric score

• 3

author list (cited authors)

• Zhang, W., Tichy, S. E., Prez, L. M., Maria, G. C., Lindahl, P. A., & Simanek, E. E.

citation count

• 54

complete list of authors

• Zhang, Wen||Tichy, Shane E||Pérez, Lisa M||Maria, Gheorghe C||Lindahl, Paul A||Simanek, Eric E

publication date

• April 2003

publisher

• American Chemical Society (ACS)  Publisher

published in

• Journal of the American Chemical Society  Journal

keywords

• Computer Simulation
• Disulfides
• Dithiothreitol
• Glutathione
• Kinetics
• Mass Spectrometry
• Models, Molecular
• Molecular Weight
• Polymers
• Structure-Activity Relationship
• Sulfhydryl Compounds
• Triazines

PubMed Central ID

• 12708859

Digital Object Identifier (DOI)

• 10.1021/ja0210906

start page

• 5086

end page

• 5094

volume

• 125

issue

• 17

URL

• http://dx.doi.org/10.1021/ja0210906