A labeled guanidine ligand for studying sweet taste
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A synthesis of a biotinylated-, coumarin-substituted-N,N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for affinity purification.
author list (cited authors)
Feng, Y., Burgess, K., Pledger, D., Cairns, N., & Linthicum, D. S.