Functionalization of the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) core. Academic Article uri icon


  • The new BODIPY systems 1 and 2 were prepared and then used as substrates to explore S(N)Ar and F-B displacement reactions. Chloride was easily displaced from 1 by a piperidine/ester, methylmagnesium bromide selectively displaced fluoride, and cyanide could attack both sites. System 2 readily added soft nucleophiles to the electrophilic carbon atoms, providing a new method for bioconjugation of BODIPYs to proteins while also introducing a (19)F probe.

published proceedings

  • Bioorg Med Chem Lett

altmetric score

  • 3

author list (cited authors)

  • Li, L., Nguyen, B., & Burgess, K.

citation count

  • 139

complete list of authors

  • Li, Lingling||Nguyen, Binh||Burgess, Kevin

publication date

  • May 2008