Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.
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Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/-turn/sheet motif.
author list (cited authors)
Raghuraman, A., Ko, E., Perez, L. M., Ioerger, T. R., & Burgess, K.
complete list of authors
Raghuraman, Arjun||Ko, Eunhwa||Perez, Lisa M||Ioerger, Thomas R||Burgess, Kevin