Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics. uri icon

abstract

  • Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/-turn/sheet motif.

published proceedings

  • J Am Chem Soc

author list (cited authors)

  • Raghuraman, A., Ko, E., Perez, L. M., Ioerger, T. R., & Burgess, K.

citation count

  • 55

complete list of authors

  • Raghuraman, Arjun||Ko, Eunhwa||Perez, Lisa M||Ioerger, Thomas R||Burgess, Kevin

publication date

  • August 2011