Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands. uri icon

abstract

  • Analogously to the fenchyl and adamantyl groups, the bornyl and epimeric isobornyl groups are compact lipophilic substituents that can be incorporated into drug design to improve pharmacological or physicochemical properties. Methods are reported for the synthesis and characterization of 2-substituted norbornanes and bornanes that can serve as novel cannabinergic ligand intermediates.

published proceedings

  • Tetrahedron Lett

altmetric score

  • 6

author list (cited authors)

  • Duclos, R. I., Lu, D., Guo, J., & Makriyannis, A.

citation count

  • 16

complete list of authors

  • Duclos, Richard I||Lu, Dai||Guo, Jianxin||Makriyannis, Alexandros

publication date

  • January 2008