Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands. Academic Article

abstract

• Analogously to the fenchyl and adamantyl groups, the bornyl and epimeric isobornyl groups are compact lipophilic substituents that can be incorporated into drug design to improve pharmacological or physicochemical properties. Methods are reported for the synthesis and characterization of 2-substituted norbornanes and bornanes that can serve as novel cannabinergic ligand intermediates.

authors

• Lu, Dai

published proceedings

• Tetrahedron Lett

altmetric score

• 6

author list (cited authors)

• Duclos, R. I., Lu, D., Guo, J., & Makriyannis, A.

citation count

• 16

complete list of authors

• Duclos, Richard I||Lu, Dai||Guo, Jianxin||Makriyannis, Alexandros

publication date

• January 2008

publisher

• Elsevier  Publisher

published in

• Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry  Journal

keywords

• Bornyl
• Chiral Hplc
• Isobornyl
• NMR
• Norbornane

PubMed Central ID

• 23935221

Digital Object Identifier (DOI)

• 10.1016/j.tetlet.2008.07.029

start page

• 5587

end page

• 5589

volume

• 49

issue

• 39

URL

• http://dx.doi.org/10.1016/j.tetlet.2008.07.029