Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands.
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Analogously to the fenchyl and adamantyl groups, the bornyl and epimeric isobornyl groups are compact lipophilic substituents that can be incorporated into drug design to improve pharmacological or physicochemical properties. Methods are reported for the synthesis and characterization of 2-substituted norbornanes and bornanes that can serve as novel cannabinergic ligand intermediates.
author list (cited authors)
Duclos, R. I., Lu, D., Guo, J., & Makriyannis, A.
complete list of authors
Duclos, Richard I||Lu, Dai||Guo, Jianxin||Makriyannis, Alexandros