Synthesis and characterization of a compact tricyclic resorcinol from (+)- and (−)-3-pinanol Academic Article uri icon


  • Resorcinol derivatives are important building blocks in the synthesis of natural products and pharmaceutical compounds including cannabinoids. Here we describe the synthesis and the structural characterization of a key resorcinol which carries a fully restricted bridged bicyclic group. We also report a potential mechanism for the acid catalyzed condensation of (+)- or (-)-3-pinanol with 2,6-dimethoxyphenol. The synthesized resorcinol facilitates the development of novel conformationally restricted cannabinoid analogs.

altmetric score

  • 7

author list (cited authors)

  • Lu, D., Nikas, S. P., Han, X., Parrish, D. A., & Makriyannis, A.

citation count

  • 0

publication date

  • August 2012