Synthesis and characterization of a compact tricyclic resorcinol from (+)- and (-)-3-pinanol. Academic Article uri icon

abstract

  • Resorcinol derivatives are important building blocks in the synthesis of natural products and pharmaceutical compounds including cannabinoids. Here we describe the synthesis and the structural characterization of a key resorcinol which carries a fully restricted bridged bicyclic group. We also report a potential mechanism for the acid catalyzed condensation of (+)- or (-)-3-pinanol with 2,6-dimethoxyphenol. The synthesized resorcinol facilitates the development of novel conformationally restricted cannabinoid analogs.

published proceedings

  • Tetrahedron Lett

altmetric score

  • 7

author list (cited authors)

  • Lu, D., Nikas, S. P., Han, X., Parrish, D. A., & Makriyannis, A.

citation count

  • 4

complete list of authors

  • Lu, Dai||Nikas, Spyros P||Han, Xiu-Wen||Parrish, Damon A||Makriyannis, Alexandros

publication date

  • January 1, 2012 11:11 AM