Serum α1-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease. Academic Article uri icon

abstract

  • Serum canine α1-proteinase inhibitor (cα1-PI) concentrations were evaluated in dogs with pancreatitis (n=24), exocrine pancreatic insufficiency (EPI; n=29), chronic hepatitis (CH; n=11) or proteinuric chronic kidney disease (CKD-P; n=61) to determine whether systemic proteinase/proteinase-inhibitor balance is altered in these conditions. Dogs with CKD-P had significantly lower cα1-PI concentrations than dogs with pancreatitis, EPI or CH; 16% of dogs with CKD-P had serum cα1-PI concentrations below the reference interval. Serum and urine cα1-PI concentrations were inversely correlated in dogs with CKD-P, but not in dogs with CH. This suggests that renal loss of cα1-PI contributes to decreased serum concentrations in dogs with CKD-P, while hepatic cα1-PI synthesis with CH either is not compromised or is counterbalanced by extrahepatic production.

published proceedings

  • Vet J

altmetric score

  • 0.25

author list (cited authors)

  • Heilmann, R. M., Grtzner, N., Hokamp, J. A., Lidbury, J. A., Xenoulis, P. G., Suchodolski, J. S., ... Steiner, J. M.

citation count

  • 1

complete list of authors

  • Heilmann, RM||Grützner, N||Hokamp, JA||Lidbury, JA||Xenoulis, PG||Suchodolski, JS||Nabity, MB||Cianciolo, R||Steiner, JM

publication date

  • April 2018