Larval Thymectomy of Xenopus laevis. Academic Article

abstract

• In jawed vertebrates from sharks to mammals, the thymus is the primary (or central) lymphoid tissue where T cells develop and mature. The particular stromal cell types, cytokine environment, and tissue organization in the thymus are essential for V(D)J recombination, positive selection for major histocompatibility complex recognition, and negative selection against self-peptide recognition of most T cells. The thymectomy operation on Xenopus tadpole larva described here creates a T-cell-deficient model suitable for many immunology studies.

authors

• Criscitiello, Michael

published proceedings

• Cold Spring Harb Protoc

altmetric score

• 0.75

author list (cited authors)

• Mashoof, S., Breaux, B., & Criscitiello, M. F.

citation count

• 1

complete list of authors

• Mashoof, Sara||Breaux, Breanna||Criscitiello, Michael F

publication date

• July 2018

publisher

• Cold Spring Harbor Laboratory  Publisher

published in

• Cold Spring Harbor protocols  Journal

keywords

• Animals
• Larva
• Thymectomy
• Xenopus Laevis

PubMed Central ID

• 29769397

Digital Object Identifier (DOI)

• 10.1101/pdb.prot099192

start page

• pdb.prot099192

end page

• pdb.prot099192

volume

• 2018

issue

• 7

URL

• http://dx.doi.org/10.1101/pdb.prot099192