Doxorubicin induced expression of P-glycoprotein in a canine osteosarcoma cell line. Academic Article

abstract

• Canine and human osteosarcoma are very similar with respect to clinical presentation, radiological and histopathological features, metastatic rate and pattern and response to therapy. For these reasons, canine osteosarcoma is a useful intermediate model for the disease in humans. Overexpression of P-glycoprotein, the product of the MDR1 gene, is the most important predictor of an adverse clinical course in human patients with osteosarcoma. Exposure of canine osteosarcoma cells to doxorubicin resulted in overexpression of MDR1 mRNA and P-glycoprotein. Furthermore, these cells failed to accumulate doxorubicin intracellularly and were less sensitive to vincristine-induced cytotoxicity as compared to parental cells.

authors

• Mouneimne, Roula
• Rogers, Kenita

published proceedings

• Cancer Lett

author list (cited authors)

• Mealey, K. L., Barhoumi, R., Rogers, K., & Kochevar, D. T.

citation count

• 33

complete list of authors

• Mealey, KL||Barhoumi, R||Rogers, K||Kochevar, DT

publication date

• January 1998

publisher

• Elsevier  Publisher

published in

• Cancer Letters  Journal

keywords

• Animals
• Antibiotics, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Atp Binding Cassette Transporter, Subfamily B, Member 1
• Bone Neoplasms
• Dogs
• Doxorubicin
• Drug Resistance, Multiple
• Immunoblotting
• Neoplasm Proteins
• Osteosarcoma
• Tumor Cells, Cultured
• Vincristine

Digital Object Identifier (DOI)

• 10.1016/s0304-3835(98)00004-4

start page

• 187

end page

• 192

volume

• 126

issue

• 2

URL

• http://dx.doi.org/10.1016/s0304-3835(98)00004-4