Pipped at the Post: Pipecolic Acid Derivative Identified as SAR Regulator.
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The non-protein amino acid pipecolic acid (Pip) is a lysine catabolite involved in plant systemic acquired resistance (SAR). In this issue of Cell, Hartmann etal. (2018) demonstrate that a flavin-dependent monooxygenase converts Pip to N-hydroxypipecolic acid (NHP), which functions as a critical metabolic regulator of SAR in Arabidopsis.
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