Effect of ventromedial and dorsomedial hypothalamic lesions on circadian corticosterone rhythms. Academic Article

abstract

• Weanling rats received bilateral electrolytic lesions in the dorsomedial (DMH) or ventromedial (VMH) hypothalamic areas destroying primarily the dorsomedial (DMN) or ventromedial (VMN) hypothalamic nuclei. Sham-operated rats served as controls. Lesions in the VMN and DMN, both of which have previously been shown to disrupt normal diurnal feeding rhythms, were also observed to disrupt normal plasma corticosterone rhythms in the present study. The a.m. values of plasma corticosterone in the DMN-lesioned rats were higher than the sham-operated controls. In the p.m., the values of both VMN- and DMN-lesioned rats were lower than those of the controls but unchanged in comparison to their own a.m. concentrations. This disruption of the normal diurnal plasma corticosterone rhythm persisted for at least 9 post-operative weeks.

authors

• Bellinger, Larry

published proceedings

• Neuroendocrinology

author list (cited authors)

• Bellinger, L. L., Bernardis, L. L., & Mendel, V. E.

citation count

• 74

complete list of authors

• Bellinger, LL||Bernardis, LL||Mendel, VE

publication date

• January 1976

publisher

• Karger Publishers  Publisher

published in

• Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships  Journal

keywords

• Animals
• Circadian Rhythm
• Corticosterone
• Feeding Behavior
• Hypothalamus
• Male
• Rats

PubMed Central ID

• 1028952

Digital Object Identifier (DOI)

• 10.1159/000122628

start page

• 216

end page

• 225

volume

• 22

issue

• 3

URL

• http://dx.doi.org/10.1159/000122628