Somatic and endocrine consequences of electrolytic lesions in the epi and subthalamus of weanling and mature rats. Academic Article

abstract

• Weanling rats received lesions in the zona incerta (ZIN). Sham-operated rats served as controls. Two experiments were performed several months apart. The animals were maintained on lab chow and tap water for 30 days and then sacrificed. Ponderal and linear growth, food and water intake, water/food-intake ratio, and pituitary weights were significantly reduced in rats with ZIN lesions. Plasma, growth hormone, insulin, glucose, and body composition were normal, however. Weanling and mature rats received lesions in the medial habenula (HAB). Sham-operated rats served as controls. The experiment lasted 44 days postoperatively. In the weanling Hab-lesioned rats, body weight changes, body composition pituitary, weight, food and water intake, water/food-intake ratio, and plasma insulin were normal. Linear growth was slightly (p < 0.05) reduced. In the mature HAB-lesioned rats, all the above parameters were normal except for water intake, which was slightly (p < 0.05) reduced. The pathways by which the epi- and subthalamus may influence the observed changes--or the lack thereof--are discussed.

authors

• Bellinger, Larry

published proceedings

• Neurol Res

author list (cited authors)

• Bernardis, L. L., & Bellinger, L. L.

citation count

• 0

complete list of authors

• Bernardis, LL||Bellinger, LL

publication date

• January 1979

publisher

• Taylor & Francis  Publisher

published in

• Neurological Research  Journal

keywords

• Animals
• Animals, Suckling
• Blood Glucose
• Body Composition
• Body Height
• Body Weight
• Brain Mapping
• Diencephalon
• Drinking
• Eating
• Growth
• Growth Hormone
• Insulin
• Organ Size
• Pituitary Gland
• Rats

Digital Object Identifier (DOI)

• 10.1080/01616412.1979.11739551

start page

• 179

end page

• 185

volume

• 1

issue

• 2

URL

• http://dx.doi.org/10.1080/01616412.1979.11739551