Vagal denervations on intake of an imbalanced amino acid diet (1MB) Academic Article uri icon


  • Rats presented with an 1MB show reduced food intake (FI) within 3h, however this suppression can be attenuated by ventral vagal branch transection above (VENT), but not below (VENT-B) the hepatic vagal branch (HVB). The present study had seven groups (grps, n=7-16) with the following cuts: VENT, bilateral subdiaphragmatic vagotomy (TVAG), VENT-B, HVB + accessory coeliac (AC), HVB + ventral gastric branch (VGB), HVB, and sham. Diets were milk (3d), casein gel (5d), and low protein basal diet (8d). The last two days on the basal diet starting at lights out FI was recorded at 3, 6, 12, and 24h intervals. The rats were then presented with an 1MB with interval measurements and then daily measurements for 7d. The first day on 1MB the VENT grp had the highest FI and the VENT-B group the lowest. The body weight (BW, as a % of starting BW) of the VENT-B remained low and was (P<0.05) lower than all grps by day 7 on the 1MB. The TVAG had the highest BW which was higher than all grps by day 7. BW was elevated at an intermediate level in the VENT and HVB+VGB grps . The data show that the AC branch probably doesn't play a role in the FI response to the 1MB, while combination cut of the HVB and VGB enhances BW recovery.

published proceedings

  • FASEB Journal

author list (cited authors)

  • Pavelka, B., Lucente, J., Williams, F. E., Bellinger, L. L., & Gietzen, D. W.

complete list of authors

  • Pavelka, B||Lucente, J||Williams, FE||Bellinger, LL||Gietzen, DW

publication date

  • December 1996