Effect of blocking sympathetic (symp) and vagal (vag) efferents on intake of an isoleucine imbalanced amino acid diet (1MB)
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Rats given an 1MB reduce their food intake (FI) within 3 h; FI recovers over the next few days. In the present study 4 groups (grps, n = 10-12) of male S.D. rats had their ventral vagal trunk cut below the hepatic branch (VENT-B) and four grps (n=ll-12) were sham-operated (S). Diets were milk (3d), casein gel (5d), and low protein basal (8d). On the basal diet the rats were injected with saline (SAL) and FI recorded at 3, 6, 12, and 24h intervals. The grps were then injected with either SAL, Scopolamine (SCO, 0.5 mg, every 9h, 3x), Phenoxybenzamine (PHEN, a blocker, l mg/kg), or Nadolol (NAD, blocker, Smg/kg) 0.5h prior to giving an 1MB. SCO suppressed the 12 and 24h FI of both grps, whereas FI was elevated in the S-PHEN grp. On day 2 the AVB-NAD grps' FI was higher than the SNAD or S-SAL grps, while the AVB-PHEN grps' FI was greater than the SHAM-SAL grp, but not the SHAM-PHEN grp whose FI remained high. This pattern continued on days 3-4. Body weight (BW) changes were reflective of FI and by day 7 the BW of the S-SAL, S-SCO and S-NAD grps was less than the other grps. The data suggest that blocking SYMP efferents acts synergistically with VENT-B to increase intake of 1MB.
