The effect of dorsomedial hypothalamic nucleus (DMN) Knife Cuts (KC) on intake of an imbalanced amino acid diet (IMB)
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abstract
Rats eating an IMB show reduced food intake (FI) within 3h, but this can be attenuated by electrolytic lesions of the DMN. Rats for the present study were control (CON) or received KC anterior (ANT), posterior (POS), dorsal (DOR), ventral (VEN), or lateral (LAT) to the DMN and then received a chow diet (7d), low protein basal diet (8d), and then isoleucine IMB (7d). The last 2d on the basal diet, starting at lights out, FI was recorded at 3, 6, 12, and 24h intervals. The rats were switched to the IMB and interval (1d) and daily (6d) intake recorded as a percentage of their basal intake. At the end of the basal diet period all KC groups, except the LAT, showed the typical DMNL hypophagia and reduced body weight (BW). Three hours after introduction of the IMB the ANT, DOR, VEN, and LAT consumed more (P<0.05) 1MB than the CON group. At the 6, 12, and 24h measurement the ANT continued to eat more (P<0.05) than the CON. Over the next 6d, the groups' intake of IMB or their BW changes (as percentage of the last day on basal diet BW) did not differ. These latter findings are in contrast to rats with DMN electrolytic lesions that do not adapt normally to an IMB. The data suggest DMN pathways are involved in the early detection of IMB.
