Influence of chronic creatine supplementation on hepatorenal function
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Previous short-term supplementation studies with creatine (CR) have suggested no impact on hepatorenal function indices We are unaware of any long term high dose supplement studies assessing these variables. As part of a double blind, placebo controlled study with CR examining changes blood lipids, we performed routine fasting clinical chemistry panels on 34 subjects (20 CR, 14 PL; Mean age 50.9 3 yrs) at baseline, 4 and 8 weeks of supplementation, and 4 weeks after withdrawal. CR administration was 20 g/d for 5 days and 10 g/d for 51 days of pure CR, (Phosphagen(tm): Exper.A Appl Sciences, Golden, CO) Pooled male (n=9) and female (n=l 1) CR values are (Mean SEM; p < 0 04, Wk 8 > Base, Wk 12; a p < 04. Wk 8 > Base. Wk 4V Marker Budint Week 4 week g itekll Total Protein (g/dL) 7.070.12 7.080.11 7.430.12a 7.340.09 Creatinine (mg/dL) 1.120.05 1.1 1.100.05 1.130.06 I.130.04 Bllirubin (U/L) 0.660.07 0.660.06 0.590.06 0.690.06 BUN (mg/dL) 15.80.7 14.20.4 15.40.7 13.81.0 HUN Females 11 80.7 12909 13.807 11.21.1 No significant increase in serum Creatinine was noted throughout the duration of this study, despite the intake of 10-20 g of CR dairy. Only in females did BUN increase, after 8 weeks of supplementation, falling to baseline concentrations after cessation of CR. Since dietary protein intake was not recorded, we are unable to rule out the contribution of protein intake to this elevation. These data suggest that chronic high dose CR supplementation elicits minimal changes in the markers of the renal and heoatic function that were evaluated.
