Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs
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Retinoids elicit their biological actions by activating nuclear receptors that regulate gene transcription. There are six known retinoid receptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analogs and discuss the structural features that impart RAR and RXR activation properties to compounds of this class. © 1994.
author list (cited authors)
Beard, R. L., Gil, D. W., Marler, D. K., Henry, E., Colon, D. F., Gillett, S. J., ... Chandraratna, R.