Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs Academic Article uri icon


  • Retinoids elicit their biological actions by activating nuclear receptors that regulate gene transcription. There are six known retinoid receptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analogs and discuss the structural features that impart RAR and RXR activation properties to compounds of this class. 1994.

published proceedings

  • Bioorganic & Medicinal Chemistry Letters

author list (cited authors)

  • Beard, R. L., Gil, D. W., Marler, D. K., Henry, E., Colon, D. F., Gillett, S. J., ... Chandraratna, R.

citation count

  • 26

complete list of authors

  • Beard, Richard L||Gil, Daniel W||Marler, Deborah K||Henry, Elizabeth||Colon, Diana F||Gillett, Samuel J||Arefieg, Taghreed||Breen, Timothy S||Krauss, Heather||Davies, Peter JA||Chandraratna, Roshantha AS

publication date

  • January 1994