Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs Academic Article

abstract

• Retinoids elicit their biological actions by activating nuclear receptors that regulate gene transcription. There are six known retinoid receptors which belong to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) families. We report RXR-active stilbene retinoid analogs and discuss the structural features that impart RAR and RXR activation properties to compounds of this class. 1994.

authors

• Davies, Peter

published proceedings

• Bioorganic & Medicinal Chemistry Letters

author list (cited authors)

• Beard, R. L., Gil, D. W., Marler, D. K., Henry, E., Colon, D. F., Gillett, S. J., ... Chandraratna, R.

citation count

• 26

complete list of authors

• Beard, Richard L||Gil, Daniel W||Marler, Deborah K||Henry, Elizabeth||Colon, Diana F||Gillett, Samuel J||Arefieg, Taghreed||Breen, Timothy S||Krauss, Heather||Davies, Peter JA||Chandraratna, Roshantha AS

publication date

• January 1994

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(01)80511-4

start page

• 1447

end page

• 1452

volume

• 4

issue

• 12

URL

• http://dx.doi.org/10.1016/s0960-894x(01)80511-4