Nonpeptide HIV protease inhibitors designed to replace a bound water
Academic Article
Overview
Research
Identity
Additional Document Info
Other
View All
Overview
abstract
Cyclic nonpeptide molecules were designed and synthesized with the goal of displacing the conserved flap-associated water of HIV-1 protease. Several such molecules were competitive inhibitors with micromolar inhibition constants, and their structure-activity relationships were consistent with the design hypothesis. 1993.