Nonpeptide HIV protease inhibitors designed to replace a bound water Academic Article uri icon

abstract

  • Cyclic nonpeptide molecules were designed and synthesized with the goal of displacing the conserved flap-associated water of HIV-1 protease. Several such molecules were competitive inhibitors with micromolar inhibition constants, and their structure-activity relationships were consistent with the design hypothesis. 1993.

published proceedings

  • Bioorganic & Medicinal Chemistry Letters

altmetric score

  • 6

author list (cited authors)

  • Chenera, B., DesJarlais, R. L., Finkelstein, J. A., Eggleston, D. S., Meek, T. D., Tomaszek, T. A., & Dreyer, G. B.

citation count

  • 15

complete list of authors

  • Chenera, Balan||DesJarlais, Renee L||Finkelstein, Joseph A||Eggleston, Drake S||Meek, Thomas D||Tomaszek, Thaddeus A||Dreyer, Geoffrey B

publication date

  • December 1993