Nonpeptide HIV protease inhibitors designed to replace a bound water
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Cyclic nonpeptide molecules were designed and synthesized with the goal of displacing the conserved flap-associated water of HIV-1 protease. Several such molecules were competitive inhibitors with micromolar inhibition constants, and their structure-activity relationships were consistent with the design hypothesis. © 1993.
author list (cited authors)
Chenera, B., DesJarlais, R. L., Finkelstein, J. A., Eggleston, D. S., Meek, T. D., Tomaszek, T. A., & Dreyer, G. B.