Inactivation of HIV-1 protease by a tripeptidyl epoxide Academic Article

abstract

• (2S,3R,4S)-N-[N-(N-benzyloxycarbonyl)-L-phenylalanyl]-L-alanyl-1-phenyl- 2-amino-3,4-epoxy-6-methylheptane, a tripeptidyl epoxide analogue of peptide substrates of the retroviral protease of the human immunodeficiency virus-1, is a potent, active-site directed, irreversible inactivator of this enzyme. (2S, 3R, 4S)-N-[N-(N-benzyloxycarbonyl)-L-phenylalanyl]-L-alanyl-1-phenyl-2-amino -3,4-epoxy-6-methylheptane, a tripeptidyl epoxide analogue of peptide substrates of the retroviral protease of the human immunodeficiency virus-1, is a potent, active-site directed, irreversible inactivator of this enzyme. 1992.

authors

• Meek, Thomas

published proceedings

• Bioorganic & Medicinal Chemistry Letters

altmetric score

• 3

author list (cited authors)

• Grant, S. K., Moore, M. L., Fakhoury, S. A., Tomaszek, T. A., & Meek, T. D.

citation count

• 12

complete list of authors

• Grant, Stephan K||Moore, Michael L||Fakhoury, Stephen A||Tomaszek, Thaddeus A||Meek, Thomas D

publication date

• January 1992

publisher

• Elsevier  Publisher

published in

• Bioorganic and Medicinal Chemistry Letters  Journal

Digital Object Identifier (DOI)

• 10.1016/s0960-894x(00)80528-4

start page

• 1441

end page

• 1445

volume

• 2

issue

• 11

URL

• http://dx.doi.org/10.1016/s0960-894x(00)80528-4