Inactivation of HIV-1 protease by a tripeptidyl epoxide Academic Article uri icon

abstract

  • (2S,3R,4S)-N-[N-(N-benzyloxycarbonyl)-L-phenylalanyl]-L-alanyl-1-phenyl- 2-amino-3,4-epoxy-6-methylheptane, a tripeptidyl epoxide analogue of peptide substrates of the retroviral protease of the human immunodeficiency virus-1, is a potent, active-site directed, irreversible inactivator of this enzyme. (2S, 3R, 4S)-N-[N-(N-benzyloxycarbonyl)-L-phenylalanyl]-L-alanyl-1-phenyl-2-amino -3,4-epoxy-6-methylheptane, a tripeptidyl epoxide analogue of peptide substrates of the retroviral protease of the human immunodeficiency virus-1, is a potent, active-site directed, irreversible inactivator of this enzyme. © 1992.

altmetric score

  • 3

author list (cited authors)

  • Grant, S. K., Moore, M. L., Fakhoury, S. A., Tomaszek, T. A., & Meek, T. D.

citation count

  • 9

publication date

  • November 1992