Effect of transforming growth factor beta (TGF-beta) on ATP citrate lyase in isolated hepatocytes.

abstract

• Transforming growth factor beta (TGF-beta) activates ATP citrate lyase in freshly isolated rat liver hepatocytes in a time dependent manner. Maximal stimulation of the enzyme occurred with less than thirty minutes of incubation of the cells with TGF-beta. The half-maximal effect on the enzyme determined in hepatocytes incubated with TGF-beta for 10 min at 37 degrees C was elicited by TGF-beta concentrations in the 10-11 - 10-12 M range. The potential role of TGF-beta stimulation of ATP citrate lyase activity in new membrane synthesis is discussed.

authors

• Reinhart, Gregory

published proceedings

• Mol Cell Biochem

author list (cited authors)

• Reinhart, G., & Roehrig, K.

citation count

• 3

publication date

• October 1987

publisher

• Springer Nature  Publisher

keywords

• Animals
• Atp Citrate (pro-s)-lyase
• Cells, Cultured
• Enzyme Activation
• In Vitro Techniques
• Liver
• Male
• Neoplasm Proteins
• Peptides
• Rats
• Rats, Inbred Strains
• Transforming Growth Factors

PubMed Central ID

• 3481431

Digital Object Identifier (DOI)

• 10.1007/BF00221920

start page

• 121

end page

• 125

volume

• 77

issue

• 2

URL

• http://dx.doi.org/10.1007/bf00221920