In Vivo Response of Osteoblast-like and Odontoblast-like Cells in Intraperitoneal Diffusion Chamber Academic Article uri icon


  • Preliminary analysis of cells before using them in tissue engineering is mandatory. Thus, to clarify the behavior of cells in an appropriate experimental model, we evaluated the characteristic of MDPC-23 cells and KUSA/A1 cells in vitro and in vivo seeded in diffusion chamber. Our results indicated that KUSA/A1 cells differentiated into osteoblast-like cells and induced bone tissue inside the chamber. Whereas, MDPC-23 cells were odontoblast-like cells but with low ability to induce dentin formation. This study suggests that MDPC-23 cells are special cells, which possess morphological and functional character of odontoblast-like cells, expressing DSPP only in vivo with low capacity to induce mineralized dentin matrix. 2005, THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY. All rights reserved.

published proceedings

  • Journal of Hard Tissue Biology

author list (cited authors)

  • Rodriguez, A. P., Tsujigiwa, H., Nagatsuka, H., Ichikawa, K., Minonishi, A., Liliana, M., Qin, C. L., & Nagai, N.

citation count

  • 2

complete list of authors

  • Rodriguez, Andrea Paola||Tsujigiwa, Hidetsugu||Nagatsuka, Hitoshi||Ichikawa, Kazuo||Minonishi, Atsuhisa||Liliana, Missana||Qin, CL||Nagai, Noriyuki

publication date

  • January 2005