[The effects of nicotine on bone calcium and phosphorus content and alkaline phosphatase activity in different part of rat]. Academic Article uri icon

abstract

  • OBJECTIVE: To analyze the effects of nicotine on the bone calcium and phosphorus content and alkaline phosphatase (ALP) activity in rat alveolar bone and mandible. METHODS: Twenty health male Wistar rats of five weeks of age were randomly assigned to two groups and received daily intraperitoneal injections for three months as follows: Saline solution for control group, nicotine 0.73 mg.kg-l.d-1 for experimental group. The bone calcium phosphorus content were detected by concentrated acid digestion method and the ALP activity was examined by improved Reddi method. RESULTS: Compared to the control group, bone calcium and phosphorus content was lower in the experimental group (P<0.05), ALP activity had no statistical significance(P>0.05). Bone calcium phosphorus and ALP activity in different parts had no statistical significance (P>0.05). CONCLUSION: The nicotine reduces calcium phosphorus deposition of jaw bone, but has no obvious influence to ALP activity.

published proceedings

  • Hua Xi Kou Qiang Yi Xue Za Zhi

author list (cited authors)

  • Zhao, H., Ma, S. u., Chen, L. i., Liu, P., Xu, J., Hou, L., Chen, R., & Qin, C.

citation count

  • 0

complete list of authors

  • Zhao, Haixia||Ma, Su||Chen, Li||Liu, Peihong||Xu, Jing||Hou, Lin||Chen, Rui||Qin, Chunlin

publication date

  • June 2013