Mixing and combustion of engine combustion network Spray A after end of injection are modeled using highly resolved multidimensional numerical simulations to explore the physics underlying recent experimental observations of combustion recession. Reacting spray simulations are performed using a traditional Lagrangian–Eulerian coupled formulation for two-phase mixture transport with a Reynolds-averaged Navier–Stokes approach using the open-source computational fluid dynamics code OpenFOAM. Chemical kinetics models for n-dodecane by Cai et al. and Yao et al. are deployed to evaluate the impact of mechanism formulation and low-temperature chemistry on predictions of combustion recession behavior. Simulations with the Cai mechanism show that under standard Spray A conditions, the end-of-injection transient induces second-stage ignition in distinct regions near the nozzle that are initially spatially separated from the lifted diffusion flame, but then rapidly merge with flame. By contrast, the Yao mechanism fails to predict sufficient low-temperature chemistry in mixtures upstream of the diffusion flame during the end-of-injection transient and does not predict combustion recession for the same conditions. The effects of the shape and duration of the end-of-injection transient on the entrainment wave near the nozzle, the likelihood of combustion recession, and the spatiotemporal development of mixing and chemistry in near-nozzle mixtures are also investigated. With a more rapid ramp-down injection profile (ramp-down duration < 400 µs), a weaker combustion recession occurs earlier in time after the start of ramp-down. For extremely fast ramp-down (ramp-down duration = 0), the entrainment flux varies rapidly near the nozzle and over-leaning of the mixture completely suppresses combustion recession. For a slower ramp-down profile with respect to the standard Spray A condition, complete combustion recession back toward the nozzle is observed and combustion recession occurred later in time. Simulations qualitatively agreed with the past experimental and modeling observations of combustion recession with different end-of-injection transients.