Aging-associated chronic mast cell activation by aged mesenteric lymphatic vessels Conference Paper uri icon


  • Abstract Here we present novel data related to interactions between lymphatic vessels, mast cells (MCs), eosinophils, and immune cells. MCs are known to inhabit in greater density the tissue near mesenteric lymphatic vessels (MLVs). Acute activation induces MC degranulation with subsequent recruitment of eosinophils and of MHC class II+ cells towards MLVs. Aging permanently influences mesenteric MCs by inducing chronic basal activation, thereby influencing contractility of aged MLVs. At the same time, the number of intact MCs available to react acutely to inflammatory stimuli decreases with age. The diminished number and activity of MCs in aged tissues also diminishes traffic and activation of eosinophils that are attracted to aged MLVs. Concurrently, MCs can function as helper cells for B cells that can produce IgE. IgE has a relatively short half-life in the absence of chronic MC activation. We propose that a key component of aging-associated alterations of mesenteric lymphatic system-mast cells/eosinophils-inflammatory cells system is the increased basal activation of resident MCs in aged mesentery that promote chronic inflammation with lesser potential to recruit enough anti-inflammatory MHC class II+ cells and eosinophils towards MLVs, resulting in the inability to prevent a smooth transition from acute inflammation to specific immune cell activation.

published proceedings


author list (cited authors)

  • Gashev, A., Nizamutdinova, I., Chatterjee, V., Cromer, W., Tobin, R., Zawieja, D., & Rogers, K. N.

citation count

  • 1

complete list of authors

  • Gashev, Anatoliy||Nizamutdinova, Irina||Chatterjee, Victor||Cromer, Walter||Tobin, Richard||Zawieja, David||Rogers, Karen Newell

publication date

  • May 2015