Citrus Increases Antioxidant Status and Improves Bone Quality in Orchidectomized Rats
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abstract
An experiment was conducted to evaluate the effect of feeding orange pulp on plasma antioxidant status and bone quality in orchidectomized rats. Forty-five oneyear-old male rats were randomly placed in a sham-control group and four orchidectomized (ORX) group, ORX + 2.5% orange pulp (OP); ORX + 5.0% OP; ORX + 10.0% OP. Four months after the study began, all rats were sacrificed and the plasma and bone were collected. The ORX did not (P > 0.1) affect red blood cell hemolysis percentage, decreased (P < 0.05) plasma IGF-I concentration, bone density, femoral strength, time induced femoral fracture, calcium and magnesium concentrations in the femur and the lumbar vertebra. Also, there was an increased (P < 0.05) urinary deoxypyridinoline, calcium and magnesium excretions compared to the sham group. Feeding 2.5% OP tended to increase IGF-I while it increased (P< 0.05) bone density, femoral strength, and time induced femoral fracture. Feeding 10% OP profoundly (P<0.05) improved antioxidant status by protecting red blood cells against hemolysis, increased (P<0.05) the plasma IGF-I, bone density and bone mineral content, and decreased (P<0.05) urinary magnesium and urinary deoxypyridinoline excretion. In conclusion, citrus positively affects bone quality by enhancing bone mineral deposition in orchidectomized rats and by improving bone density in sham rats via an undefined mechanism.
