Preliminary study of light-cured hydrogel for endodontic drug delivery vehicle. Academic Article uri icon

abstract

  • AIM: Direct pulp capping is the treatment of an exposed vital pulp with a dental material to facilitate the formation of reparative dentin and maintenance of vital pulp. A bioengineered drug delivery vehicle has the potential to increase the success rate of pulp capping. The aim of this study was to develop an injectable and light-curing drug delivery vehicle for endodontic treatment including direct pulp capping. METHODS: Polyethylene glycol-maleate-citrate (PEGMC) hydrogel was synthesized as a drug delivery vehicle that is composed of PEGMC (45% w/v), acrylic acid (AA) (5% w/v), 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) (0.1% w/v), and deionized water. The association between prehydrogel-solution volume and visible light-curing was examined. The cytotoxicity of the hydrogel was tested using L929 cells in a cell culture system. Ca(2+) release from the hydrogel was determined using calcium hydroxide as the incorporated medicine. RESULTS: The results showed that the light-curing time for hydrogel is comparable to composite resin. The hydrogel had cell toxicity similar to adhesive systems. Moreover, controlled Ca(2+) release was obtained from the calcium hydroxide incorporated hydrogel. CONCLUSIONS: The data suggest that hydrogel should be explored further as a promising drug delivery vehicle for vital pulp therapy and regenerative endodontics.

published proceedings

  • J Investig Clin Dent

altmetric score

  • 1.25

author list (cited authors)

  • Komabayashi, T., Wadajkar, A., Santimano, S., Ahn, C., Zhu, Q., Opperman, L. A., ... Nguyen, K. T.

citation count

  • 13

complete list of authors

  • Komabayashi, Takashi||Wadajkar, Aniket||Santimano, Sonia||Ahn, Chul||Zhu, Qiang||Opperman, Lynn A||Bellinger, Larry L||Yang, Jian||Nguyen, Kytai T

publication date

  • February 2016

publisher