Pyrogallol, a microbial metabolites from mango tannins (Mangifera Indica L.) suppresses breast cancer ductal carcinoma in situ proliferation in both in vitro and in vivo
Conference Paper
Overview
Identity
Additional Document Info
Other
View All
Overview
abstract
It is estimated that 1 in 10 newly diagnosed cancer cases will be female breast cancer, and therefore there is an ongoing need to research novel treatment options. Polyphenolics are secondary plant metabolites that have been shown to have anticancer effects in multiple cancer models without the deleterious side effects of conventional small molecules. This research, focused on the antiproliferative activities of pyrogallol, an intestinal microbial metabolite of mango polyphenols. Mice were xenographed with MCF10DCIS.COM cells in order to determine the antiproliferative of pyrogallol on ductal carcinoma in situ breast cancer (DCIS). Treatment animals received either 0.2mg/day or 0.8mg/day pyrogallol, and both treatment groups had significantly decreased tumor volumes compared to the control animals after 4 weeks of treatment. Plasma and tumor tissue was assessed in order to determine in pyrogallol or its metabolites were present in circulation or at the site of action. Additionally, biomarkers along the AMPKmTOR signaling axis were affected at mRNA, protein and phosphorylated protein levels. These results suggest that antiproliferative activities of mango polyphenols may be mediated by pyrogallol as a central bioactive metabolite that is systemically absorbed. Findings indicate that a diet rich in gallotannins that are microbially metabolized to pyrogallol may prevent the advancement of DCIS breast cancer.Support or Funding InformationMango National Board
